Dautzenberg Paul L J, Mulder Leonie J, Olde Rikkert Marcel G M, Wouters Cees J, Loonen Anton J M
Department Geriatrics Jeroen Bosch Ziekenhuis, s-Hertogenbosch, The Netherlands.
Int J Geriatr Psychiatry. 2004 Jul;19(7):641-4. doi: 10.1002/gps.1138.
To investigate the efficacy of the chronic usage of the cholinesterase inhibitor rivastigmine in patients with dementia in the prevention of delirium in case of hospitalisation.
Retrospective cohort study.
Non-geriatric wards of an 1120 bed general teaching hospital in s-Hertogenbosch, The Netherlands.
Of a group of 366 hospitalised patients, treated by the geriatric consultation team from January 2002 until June 2003, the patients who used rivastigmine chronically were compared with a randomly selected subgroup of all patients not treated with rivastigmine.
The occurrence and duration of a delirium, co-morbidity, use of medication, length of hospitalisation and psychosocial data were collected from the medical charts of the geriatric consultation team.
11 patients (3%) were chronic rivastigmine users. A control group of 29 subjects was randomly selected from the non-rivastigmine users of the patient population. In the group that used rivastigmine five patients (45.5%) developed a delirium, compared with 8 (88.9%) in the control group (p < 0.05).
Chronic rivastigmine use may contribute to the prevention of a delirium in a high-risk group of elderly hospitalised patients suffering from dementia.
研究长期使用胆碱酯酶抑制剂卡巴拉汀对痴呆患者住院时预防谵妄的疗效。
回顾性队列研究。
荷兰斯海尔托亨博斯一家拥有1120张床位的综合教学医院的非老年病房。
在2002年1月至2003年6月期间由老年病咨询团队治疗的366名住院患者中，将长期使用卡巴拉汀的患者与随机选择的未使用卡巴拉汀的所有患者亚组进行比较。
从老年病咨询团队的病历中收集谵妄的发生情况和持续时间、合并症、药物使用情况、住院时间和社会心理数据。
11名患者（3%）长期使用卡巴拉汀。从患者群体中未使用卡巴拉汀的患者中随机选择29名作为对照组。在使用卡巴拉汀的组中，5名患者（45.5%）出现谵妄，而对照组为8名（88.9%）（p<0.05）。
长期使用卡巴拉汀可能有助于预防患有痴呆症的高危老年住院患者发生谵妄。
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