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谵妄的临床最新进展:从早期识别到有效管理。

A clinical update on delirium: from early recognition to effective management.

作者信息

Cerejeira Joaquim, Mukaetova-Ladinska Elizabeta B

机构信息

Serviço de Psiquiatria, Hospitais da Universidade de Coimbra, Praceta Mota Pinto, 3000 Coimbra, Portugal.

出版信息

Nurs Res Pract. 2011;2011:875196. doi: 10.1155/2011/875196. Epub 2011 Jun 16.

DOI:10.1155/2011/875196
PMID:21994844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3169311/
Abstract

Delirium is a neuropsychiatric syndrome characterized by altered consciousness and attention with cognitive, emotional and behavioural symptoms. It is particularly frequent in elderly people with medical or surgical conditions and is associated with adverse outcomes. Predisposing factors render the subject more vulnerable to a congregation of precipitating factors which potentially affect brain function and induce an imbalance in all the major neurotransmitter systems. Early diagnosis of delirium is crucial to improve the prognosis of patients requiring the identification of subtle and fluctuating signs. Increased awareness of clinical staff, particularly nurses, and routine screening of cognitive function with standardized instruments, can be decisive to increase detection rates of delirium. General measures to prevent delirium include the implementation of protocols to systematically identify and minimize all risk factors present in a particular clinical setting. As soon as delirium is recognized, prompt removal of precipitating factors is warranted together with environmental changes and early mobilization of patients. Low doses of haloperidol or olanzapine can be used for brief periods, for the behavioural control of delirium. All of these measures are a part of the multicomponent strategy for prevention and treatment of delirium, in which the nursing care plays a vital role.

摘要

谵妄是一种神经精神综合征,其特征为意识和注意力改变,并伴有认知、情感和行为症状。在患有内科或外科疾病的老年人中尤为常见,且与不良后果相关。易感因素使个体更容易受到多种促发因素的影响,这些因素可能影响脑功能并导致所有主要神经递质系统失衡。谵妄的早期诊断对于改善需要识别细微和波动体征的患者的预后至关重要。提高临床工作人员尤其是护士的意识,以及使用标准化工具对认知功能进行常规筛查,对于提高谵妄的检出率可能具有决定性作用。预防谵妄的一般措施包括实施相关方案,以系统地识别并尽量减少特定临床环境中存在的所有风险因素。一旦识别出谵妄,应立即去除促发因素,同时改变环境并尽早让患者活动。低剂量的氟哌啶醇或奥氮平可短期使用,以控制谵妄的行为症状。所有这些措施都是谵妄预防和治疗多组分策略的一部分,其中护理起着至关重要的作用。

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本文引用的文献

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Which medications to avoid in people at risk of delirium: a systematic review.哪些药物应避免用于谵妄风险人群:系统评价。
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Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial.盐酸利伐斯的明作为常规治疗联合氟哌啶醇对重症患者谵妄持续时间和死亡率的影响:一项多中心、双盲、安慰剂对照随机试验。
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Severity of Symptoms as an Independent Predictor of Poor Outcomes in Patients with Advanced Cancer Presenting to the Emergency Department: Secondary Analysis of a Prospective Randomized Study.症状严重程度作为晚期癌症患者到急诊科就诊时不良预后的独立预测因素:一项前瞻性随机研究的二次分析
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Psychiatric Camouflage: A Case Series.精神伪装:病例系列
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Clinician and Visitor Activity Patterns in an Intensive Care Unit Room: A Study to Examine How Ambient Monitoring Can Inform the Measurement of Delirium Severity and Escalation of Care.重症监护病房内临床医生和访客的活动模式:一项关于环境监测如何为谵妄严重程度评估及护理升级提供信息的研究。
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A Cross-Sectional Survey on Nurses' Utilization of Risk Assessment and Screening for Postoperative Delirium in Older Patients Following Hip Fracture Surgery in Tertiary Hospitals in Jiangsu Province, China.中国江苏省三级医院髋部骨折手术后老年患者术后谵妄风险评估与筛查护士应用情况的横断面调查
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