Coste Joël, Bouyer Jean, Ughetto Sylvie, Gerbaud Laurent, Fernandez Hervé, Pouly Jean-Luc, Job-Spira Nadine
INSERM U569-IFR 69, Hôpital de Bicêtre, 94276 Le Kremlin-Bicêtre, France.
Hum Reprod. 2004 Sep;19(9):2014-8. doi: 10.1093/humrep/deh399. Epub 2004 Jul 15.
We aimed to assess the recent incidence trends of ectopic pregnancies (EP) in France (1992-2002).
A population-based register of all women aged 15-44 years with EP was set up in Auvergne (central France). We calculated rates of EP as a 'reproductive failure' or as a 'contraceptive failure', frequencies of exposure to the two main risk factors for EP (cigarette smoking and chlamydial infection) and contraceptive methods between 1992 and 2002.
The overall EP rate decreased by 2%, from 96.4 per 100 000 women aged 15-44 in 1992 to 95.3 per 100 000 in 2002. However, the rate of 'reproductive failure' EP increased by 17%, while the rate of 'contraceptive failure' EP, mostly intrauterine device failure, decreased by 29%.
Appropriate analysis reveals that the rate of EP as reproductive failure is increasing again in France. This result is of interest for many European and North America countries where chlamydial infections or smoking or both are increasing in women of reproductive age. The rates of EP as contraceptive failure and of that as reproductive failure evolve differently in the population and should not be confused in epidemiological studies.
我们旨在评估法国(1992 - 2002年)近期宫外孕(EP)的发病趋势。
在法国中部的奥弗涅地区建立了一个基于人群的登记系统,登记所有年龄在15 - 44岁患有宫外孕的女性。我们计算了1992年至2002年期间宫外孕作为“生殖失败”或“避孕失败”的发生率、暴露于宫外孕两个主要危险因素(吸烟和衣原体感染)的频率以及避孕方法。
总体宫外孕发生率下降了2%,从1992年每10万名15 - 44岁女性中的96.4例降至2002年的每10万名中的95.3例。然而,“生殖失败”型宫外孕的发生率上升了17%,而“避孕失败”型宫外孕的发生率,主要是宫内节育器失败,下降了29%。
恰当的分析表明,在法国,作为生殖失败的宫外孕发生率再次上升。这一结果对于许多欧洲和北美国家具有参考价值,在这些国家,育龄女性中的衣原体感染或吸烟或两者的发生率都在上升。作为避孕失败的宫外孕发生率和作为生殖失败的宫外孕发生率在人群中的变化有所不同,在流行病学研究中不应混淆。