乌干达西南部一家三级护理医院既往感染与异位妊娠之间的关联
Association between Prior Infection and Ectopic Pregnancy at a Tertiary Care Hospital in South Western Uganda.
作者信息
Mpiima Derrick Paul, Wasswa Salongo George, Lugobe Henry, Ssemujju Augustine, Mumbere Mulisya Olivier, Masinda Abraham, Twizerimana Hillary, Ngonzi Joseph
机构信息
Mbarara University of Science and Technology, Mbarara, Uganda.
出版信息
Obstet Gynecol Int. 2018 Mar 1;2018:4827353. doi: 10.1155/2018/4827353. eCollection 2018.
BACKGROUND
Increase in the number of ectopic pregnancy is attributed to increase in the incidence of pelvic infections. is responsible for most of the sexually transmitted bacterial infections. If undetected and untreated, the infection can ascend to the upper genital tract and cause pelvic inflammatory disease (PID) and related sequelae (ectopic pregnancy and tubal factor infertility).
OBJECTIVE
To determine the association between prior infection and ectopic pregnancy at Mbarara Regional Referral Hospital (MRRH).
METHODS
This was an unmatched case-control study carried out at MRRH involving 25 cases and 76 controls. Serological evidence of prior chlamydial infection was determined by testing for the presence of immunoglobulin G antibodies in their blood. Logistic regression was used to determine the association between prior infection and also the factors associated with ectopic pregnancy. The significant level of <0.05 was used. antibodies were found in 60% of patients with ectopic pregnancy and 26.3% of the controls (=0.002). The presence of antibodies was associated with a fourfold risk of ectopic pregnancy.
CONCLUSION
There was a strong association between prior infection and ectopic pregnancy.
背景
异位妊娠数量的增加归因于盆腔感染发病率的上升。[病原体名称]是大多数性传播细菌感染的病原体。如果未被发现和治疗，感染可上行至生殖道上部，导致盆腔炎（PID）及相关后遗症（异位妊娠和输卵管因素不孕）。
目的
确定姆巴拉拉地区转诊医院（MRRH）既往[病原体名称]感染与异位妊娠之间的关联。
方法
这是一项在MRRH开展的非匹配病例对照研究，涉及25例病例和76例对照。通过检测血液中[病原体名称]免疫球蛋白G抗体的存在来确定既往衣原体感染的血清学证据。采用逻辑回归分析来确定既往[病原体名称]感染与异位妊娠之间的关联以及与异位妊娠相关的因素。使用的显著性水平为<0.05。在60%的异位妊娠患者和26.3%的对照中发现了[病原体名称]抗体（P = 0.002）。[病原体名称]抗体的存在与异位妊娠风险增加四倍相关。
结论
既往[病原体名称]感染与异位妊娠之间存在密切关联。
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