以精神状态改变和其他神经系统表现为特征的柔脑膜骨髓瘤病
Leptomeningeal myelomatosis presenting with mental status changes and other neurologic findings.
作者信息
Leifer D, Grabowski T, Simonian N, Demirjian Z N
机构信息
Department of Neurology, Massachusetts General Hospital, Boston.
出版信息
Cancer. 1992 Oct 1;70(7):1899-904. doi: 10.1002/1097-0142(19921001)70:7<1899::aid-cncr2820700716>3.0.co;2-3.
BACKGROUND
Leptomeningeal myelomatosis is a rare complication of multiple myeloma.
METHODS
The authors identified and studied three patients with leptomeningeal myelomatosis and reviewed previous case reports of this condition.
RESULTS
The patients described here had intermittent abnormalities in mental status or cranial nerve and brain stem abnormalities. Two of the patients responded dramatically, though transiently, to treatment. In one patient, the clinical findings correlated with lesions visualized by gadolinium-enhanced magnetic resonance imaging.
CONCLUSIONS
These patients are typical of those reported previously. Patients with leptomeningeal myelomatosis often have a good response to treatment initially, but long-term survival is rare.
背景
柔脑膜骨髓瘤病是多发性骨髓瘤的一种罕见并发症。
方法
作者识别并研究了3例柔脑膜骨髓瘤病患者，并回顾了此前关于该病症的病例报告。
结果
此处描述的患者存在精神状态间歇性异常或颅神经及脑干异常。2例患者对治疗反应显著，尽管是短暂的。1例患者的临床发现与钆增强磁共振成像显示的病变相关。
结论
这些患者与此前报告的患者典型特征相符。柔脑膜骨髓瘤病患者通常最初对治疗反应良好，但长期存活罕见。
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