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多发性骨髓瘤伴软脑膜受累并发多发性颅神经麻痹：一例报告并文献复习

Multiple Cranial Nerve Palsy Concomitant with Leptomeningeal Involvement in Multiple Myeloma: A Case Report and Review of Literature.

作者信息

Pak Neda, Shakki Katouli Fatemeh, Radmard Amir Reza, Shaki Katuli Mohammad Hassan, Rezwanifar Mohamad Mehdi, Sepehri Boroujeni Negar

机构信息

Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Int J Hematol Oncol Stem Cell Res. 2018 Jan 1;12(1):8-13.

PMID:29951172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6018249/
Abstract

Neurologic symptoms are quite common in multiple myeloma, but direct invasion of central nervous system is extremely rare. Leptomeningeal multiple myeloma, as a rare neurological manifestation of multiple myeloma, presents with impairment of consciousness, cranial nerve palsies and convulsions. Here, we describe a 52-year- old male patient, known case of multiple myeloma, who presented with bilateral visual loss and difficulty in swallowing.

摘要

神经系统症状在多发性骨髓瘤中相当常见，但中枢神经系统的直接侵犯极为罕见。软脑膜多发性骨髓瘤作为多发性骨髓瘤一种罕见的神经表现，表现为意识障碍、颅神经麻痹和惊厥。在此，我们描述一名52岁男性患者，他是已知的多发性骨髓瘤病例，出现双侧视力丧失和吞咽困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f6/6018249/f50e1c8aa84e/IJHOSCR-12-8-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f6/6018249/23d58c5894f8/IJHOSCR-12-8-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f6/6018249/6b81e6864b42/IJHOSCR-12-8-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f6/6018249/76f8b3ecd373/IJHOSCR-12-8-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f6/6018249/f50e1c8aa84e/IJHOSCR-12-8-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f6/6018249/23d58c5894f8/IJHOSCR-12-8-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f6/6018249/6b81e6864b42/IJHOSCR-12-8-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f6/6018249/76f8b3ecd373/IJHOSCR-12-8-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f6/6018249/f50e1c8aa84e/IJHOSCR-12-8-g004.jpg

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Diplopia as the initial symptom of multiple myeloma in a patient with sarcoidosis.

本文引用的文献

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2
Overview of recent trends in diagnosis and management of leptomeningeal multiple myeloma.柔脑膜多发性骨髓瘤的诊断与管理近期趋势概述
Hematol Oncol. 2016 Mar;34(1):2-8. doi: 10.1002/hon.2185. Epub 2014 Dec 19.
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MRI negative meningeal myeloma with abducens nerve palsies responding to intrathecal chemotherapy.MRI检查呈阴性的脑膜骨髓瘤伴展神经麻痹，鞘内化疗有效
复视作为一名结节病患者多发性骨髓瘤的初始症状。
BMJ Case Rep. 2020 Aug 24;13(8):e235725. doi: 10.1136/bcr-2020-235725.
J Neurol Sci. 2014 Dec 15;347(1-2):359-60. doi: 10.1016/j.jns.2014.10.005. Epub 2014 Oct 29.
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Myelomatous meningitis evaluated by multiparameter flow cytometry : report of a case and review of the literature.多参数流式细胞术评估的骨髓瘤性脑膜炎：一例报告及文献复习
J Clin Exp Hematop. 2014;54(2):129-36. doi: 10.3960/jslrt.54.129.
5
Optic nerve and dura mater involvement as the first sign of multiple myeloma.视神经和硬脑膜受累作为多发性骨髓瘤的首发症状
Eur J Ophthalmol. 2015 Jan-Feb;25(1):77-9. doi: 10.5301/ejo.5000489. Epub 2014 May 12.
6
Extramedullary involvement in multiple myeloma.多发性骨髓瘤的髓外浸润
Haematologica. 2012 Nov;97(11):1618-9. doi: 10.3324/haematol.2012.078519.
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Acta Neurol Taiwan. 2011 Sep;20(3):209-12.
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