Department of Radiation Oncology, Medical University of South Carolina, 169 Ashley Avenue, Charleston, SC 29425, USA.
Jpn J Radiol. 2011 Aug;29(7):513-6. doi: 10.1007/s11604-011-0577-7. Epub 2011 Sep 1.
Central nervous system (CNS) involvement by multiple myeloma is a rare complication that occurs in less than 1% of cases. The purpose of this report is to highlight the unique presentation and treatment of a patient with CNS myelomatosis. A 58-year-old Caucasian woman with multiple myeloma developed subacute vision loss bilaterally and was found to have plasma cells in her cerebrospinal fluid. Using a helmet field to 25 Gy in 10 fractions, her vision was stabilized with radiotherapy. After developing right upper extremity numbness and weakness, magnetic resonance imaging revealed intramedullary spinal cord lesions from C5 to C7. She received radiotherapy to 25 Gy in 10 fractions from C4 to T1, with improvement in upper extremity strength after 15 Gy. Although CNS involvement by multiple myeloma is a rare complication, increasing awareness is necessary for clinicians to consider meningeal myelomatosis in patients with this neoplasm.
中枢神经系统（CNS）多发性骨髓瘤累及是一种罕见的并发症，不到 1%的病例会发生。本报告旨在强调一例 CNS 骨髓瘤患者的独特表现和治疗方法。一名 58 岁的白人女性患有多发性骨髓瘤，出现双侧亚急性视力丧失，并发现脑脊液中有浆细胞。使用头盔式野 25 Gy/10 次，放疗稳定了她的视力。在出现右侧上肢麻木和无力后，磁共振成像显示 C5 至 C7 脊髓内有病变。她接受了 C4 至 T1 的 25 Gy/10 次放疗，在 15 Gy 后上肢力量得到改善。尽管 CNS 多发性骨髓瘤累及是一种罕见的并发症，但临床医生需要提高认识，在有这种肿瘤的患者中考虑脑膜骨髓瘤。
