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曲安奈德有助于在因黄斑裂孔导致视网膜脱离的高度近视眼中去除视网膜前膜并分离残留的玻璃体皮质。

Triamcinolone acetonide facilitates removal of the epiretinal membrane and separation of the residual vitreous cortex in highly myopic eyes with retinal detachment due to a macular hole.

作者信息

Yamamoto Narumichi, Ozaki Noriko, Murakami Kimio

机构信息

Department of Ophthalmology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.

出版信息

Ophthalmologica. 2004 Jul-Aug;218(4):248-56. doi: 10.1159/000078615.

Abstract

PURPOSE

To study the usefulness of intravitreal triamcinolone acetonide injection during vitrectomy in highly myopic eyes with retinal detachment due to a macular hole.

METHODS

Pars plana vitrectomy was performed in 6 patients with retinal detachment resulting from a highly myopic eye with a macular hole. After separation of the posterior hyaloid and removal of any visible epiretinal membrane, triamcinolone acetonide was injected over the posterior pole. Excised specimens were evaluated by transmission electron microscopy.

RESULTS

Upon injection of triamcinolone acetonide, the entire epiretinal membrane and residual vitreous cortex could be visualized in all patients. The epiretinal membrane and residual posterior vitreous cortex were completely removed. Successful reattachment was performed without retinal damage in all cases. Electron microscopy revealed a cellular epiretinal membrane within a collagenous matrix lining the smooth internal surface of the internal limiting membrane. No complications related to the use of triamcinolone acetonide were encountered.

CONCLUSION

Intraoperative visualization of the epiretinal membrane and residual posterior vitreous cortex with triamcinolone acetonide was found to be a useful adjunct to vitrectomy. Using triamcinolone acetonide during vitrectomy may facilitate both removal of the epiretinal membrane around the macular hole and separation of the residual vitreous cortex from the retina in highly myopic eyes with retinal detachment.

摘要

目的

研究玻璃体腔注射曲安奈德在高度近视眼黄斑裂孔性视网膜脱离玻璃体切除术中的应用价值。

方法

对6例高度近视眼黄斑裂孔性视网膜脱离患者行玻璃体切除术。在分离后玻璃体膜并切除可见的视网膜前膜后,于后极部注射曲安奈德。切除的标本行透射电子显微镜检查。

结果

注射曲安奈德后,所有患者的视网膜前膜及残留玻璃体皮质均清晰可见。视网膜前膜及残留的后玻璃体皮质均被完全切除。所有病例均成功实现视网膜复位且未造成视网膜损伤。电子显微镜检查显示,在视网膜内界膜光滑内表面的胶原基质内有一层细胞性视网膜前膜。未出现与曲安奈德使用相关的并发症。

结论

术中使用曲安奈德使视网膜前膜及残留后玻璃体皮质可视化,是玻璃体切除术的一项有用辅助手段。在高度近视眼黄斑裂孔性视网膜脱离的玻璃体切除术中使用曲安奈德,可能有助于切除黄斑裂孔周围的视网膜前膜,并使残留玻璃体皮质与视网膜分离。

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