5-酰氧基肟基-5-脱氧阿维菌素B1衍生物的合成及其杀虫活性

Synthesis and insecticidal activity of 5-acyloxyimino-5-deoxyavermectin B1 derivatives.

作者信息

Liu Xiguang, Wu Jingping, Liang Xiaomei, Wang Daoquan

机构信息

Key Laboratory of Pesticide Chemistry and Application Technology, Department of Applied Chemistry, China Agricultural University, Beijing 100094, People's Republic of China.

出版信息

Pest Manag Sci. 2004 Jul;60(7):697-702. doi: 10.1002/ps.859.

DOI:10.1002/ps.859

PMID:15260302

Abstract

Four novel 5-acyloxyimino-5-deoxyavermectin B1 compounds have been synthesized from avermectin B1 by selective oxidization of the hydroxy group at C-5, followed by oximation and convenient esterification. Their structures were confirmed by IR, 1H NMR, 13C NMR and MS. Insecticidal activities of the intermediate oxime and the four new acyl derivatives were evaluated against Helicoverpa armigera, Spodoptera exigua and Musca domestica.

摘要

通过对阿维菌素B1中C-5位羟基进行选择性氧化，随后进行肟化反应和简便的酯化反应，合成了四种新型的5-酰氧基肟基-5-脱氧阿维菌素B1化合物。通过红外光谱（IR）、核磁共振氢谱（1H NMR）、核磁共振碳谱（13C NMR）和质谱（MS）对其结构进行了确证。对中间体肟和四种新型酰基衍生物针对棉铃虫、甜菜夜蛾和家蝇进行了杀虫活性评价。