Dautry-Varsat Alice, Balañá María Eugenia, Wyplosz Benjamin
Unité de Biologie des Interactions Cellulaires, Institut Pasteur, URA CNRS 2582, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.
Traffic. 2004 Aug;5(8):561-70. doi: 10.1111/j.1398-9219.2004.00207.x.
Bacteria of the Chlamydiales order are very successful intracellular organisms that grow in human and animal cells, and even in amoebae. They fulfill several essential functions to enter their host cells, establish an intracellular environment favorable for their multiplication and exit the host cell. They multiply in a unique organelle called the inclusion, which is isolated from the endocytic but not the exocytic pathway. A combination of host cell factors and of proteins secreted by the bacteria, from within the inclusion, contribute to the establishment and development of this inclusion. Here we review recent data on the entry mechanisms and maturation of the inclusion.
衣原体目细菌是非常成功的细胞内生物，可在人类和动物细胞甚至变形虫中生长。它们为进入宿主细胞、建立有利于其繁殖的细胞内环境并离开宿主细胞发挥多种重要功能。它们在一种称为包涵体的独特细胞器中繁殖，该包涵体与内吞途径隔离，但不与外排途径隔离。宿主细胞因子和细菌从包涵体内分泌的蛋白质共同作用，促进了包涵体的形成和发展。在此，我们综述了有关包涵体进入机制和成熟的最新数据。
