Moore U J, Seymour R A, Rawlins M D
Department of Oral Surgery, University of Newcastle upon Tyne, England.
Clin Pharmacol Ther. 1992 Sep;52(3):292-6. doi: 10.1038/clpt.1992.144.
This study evaluated the efficacy of and investigated the site of action of aspirin and acetaminophen placed directly into tooth sockets after bilateral third molar surgery under local anaesthesia. On completion of surgery, 12 patients received in random, blind order either a suspension of aspirin in a methyl cellulose gel (100 mg/ml) in their tooth sockets and an oral placebo or the methyl cellulose alone in their sockets and an oral dose of aspirin (50 mg). The remaining 12 patients were treated in the same fashion with use acetaminophen. Patients were asked to record their pain, at intervals, over an 8-hour period on a 10 cm visual analog scale. Significantly less pain (p less than 0.05) was recorded throughout the 8-hour investigation period after both locally placed drugs than after placebo. There was no adverse effect on healing. The peripheral activity of aspirin is confirmed, and our findings suggest that acetaminophen has a significant peripheral effect in mediating its analgesic properties in postoperative pain after third molar surgery.
本研究评估了在局部麻醉下双侧第三磨牙手术后直接将阿司匹林和对乙酰氨基酚置于牙槽窝内的疗效，并研究了其作用部位。手术完成后，12名患者按随机、盲法顺序接受治疗，一组在牙槽窝内注入阿司匹林甲基纤维素凝胶悬液（100mg/ml）并口服安慰剂，另一组在牙槽窝内仅注入甲基纤维素并口服一剂阿司匹林（50mg）。其余12名患者以同样方式接受对乙酰氨基酚治疗。要求患者在8小时内每隔一段时间用10厘米视觉模拟量表记录疼痛情况。在整个8小时的研究期间，两种局部用药后的疼痛记录均显著低于安慰剂组（p<0.05）。对愈合没有不良影响。阿司匹林的外周作用得到证实，我们的研究结果表明，对乙酰氨基酚在介导第三磨牙手术后疼痛的镇痛特性方面具有显著的外周作用。
