Cheung Chi Wai, Choi Wing Shan, Leung Yiu Yan, Lui Frances, Ng Jacobus Kwok Fu, Hei-Ho Anthony Ming, Irwin Michael Garnet
Department of Anaesthesiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
J Oral Maxillofac Surg. 2012 Jan;70(1):25-30. doi: 10.1016/j.joms.2011.03.056. Epub 2011 Aug 5.
This double-blind randomized crossover study compared the analgesic efficacy of pre- and postoperative administration of oral pregabalin 75 mg using a postsurgical dental pain model.
Patients requiring third molar surgery in 2 separate stages under local anesthesia were recruited. They were given pregabalin 75 mg either 1 hour before or after their first surgical extraction. They then received the same dose of pregabalin at their second surgical extraction, but those who received it before surgery received it postsurgery, and vice versa. Postoperative analgesic effects were assessed at postoperative hours 2, 4, 8, 12, 24, 48, and 72. Time to first analgesic, analgesic consumption and adverse events were also evaluated.
Forty patients were recruited, and 34 completed the study. The area under curves for numerical rating scale pain scores 1 to 24 hours were significantly lower at rest but not during mouth opening for patients receiving postoperative pregabalin (P < .048). Pain relief was similar for the period of 24 to 72 hours. No significant difference was found in time to first analgesic, total analgesic consumption, and side effects between preoperative and postoperative groups. No difference in the incidence of adverse events was noticed in relation to the timing of pregabalin administration.
Postoperative administration of oral pregabalin 75 mg appears to offer better analgesic efficacy than preoperative administration after third molar surgery under local anesthesia.
本双盲随机交叉研究采用术后牙科疼痛模型，比较了术前和术后口服75毫克普瑞巴林的镇痛效果。
招募需要在局部麻醉下分两个阶段进行第三磨牙手术的患者。他们在第一次手术拔牙前1小时或后服用75毫克普瑞巴林。然后在第二次手术拔牙时接受相同剂量的普瑞巴林，但术前服用的患者在术后服用，反之亦然。在术后2、4、8、12、24、48和72小时评估术后镇痛效果。还评估了首次镇痛时间、镇痛药物消耗量和不良事件。
招募了40名患者，34名完成了研究。术后服用普瑞巴林的患者在休息时1至24小时数字评分量表疼痛评分的曲线下面积显著较低，但张口时无显著差异（P < 0.048）。24至72小时期间的疼痛缓解情况相似。术前和术后组在首次镇痛时间、总镇痛药物消耗量和副作用方面未发现显著差异。在普瑞巴林给药时间方面，未观察到不良事件发生率的差异。
在局部麻醉下进行第三磨牙手术后，术后口服75毫克普瑞巴林似乎比术前给药具有更好的镇痛效果。
