Arnold Paul D, Zai Gwyneth, Richter Margaret A
Anxiety Disorders Clinic, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, ON M5T 1R8, Canada.
Curr Psychiatry Rep. 2004 Aug;6(4):243-54. doi: 10.1007/s11920-004-0073-1.
There is considerable evidence that genetic determinants play a major role in the etiology of anxiety. Investigations into susceptibility genes for anxiety are well underway, particularly for panic disorder and obsessive-compulsive disorder and more broadly defined anxiety-related traits, such as neuroticism and harm avoidance. This review will discuss some of the core issues related to diagnosis and molecular genetic methodology, followed by a review of recent molecular genetic findings for anxiety. The authors will attempt to highlight the numerous convergent and exciting findings. Given the rapid acceleration in knowledge of the human genome, a more definitive understanding of the genetic roots of these complex conditions may be anticipated in the relatively near future.
有大量证据表明，遗传因素在焦虑症的病因中起主要作用。对焦虑症易感基因的研究正在深入进行，特别是针对惊恐障碍和强迫症，以及更广泛定义的与焦虑相关的特质，如神经质和回避伤害。本综述将讨论一些与诊断和分子遗传学方法相关的核心问题，随后回顾焦虑症的近期分子遗传学研究结果。作者将试图突出众多趋同且令人兴奋的发现。鉴于人类基因组知识的快速增长，在相对不久的将来，有望对这些复杂病症的遗传根源有更确切的了解。
