Delorme Richard, Krebs Marie-Odile, Chabane Nadia, Roy Isabelle, Millet Bruno, Mouren-Simeoni Marie Christine, Maier Wolfgang, Bourgeron Thomas, Leboyer Marion
INSERM U 513, Faculté de Médecine, 8 rue du Général Sarrail, 94010 Créteil, France.
Neuroreport. 2004 Mar 22;15(4):699-702. doi: 10.1097/00001756-200403220-00025.
Several lines of evidence suggest that obsessive compulsive disorder (OCD) could be the consequence of glutamatergic dysfunction. We performed a case-control study in 156 patients and 141 controls and the transmission disequilibrium test in 124 parent-offspring trios to search for association between OCD and two kainate receptors, GRIK2 and GRIK3. Using three single nucleotide polymorphisms (SNP) in GRIK2 and one in GRIK3, we found no evidence for association in case-control or family-based analyses. Only the GRIK2 SNP I867, recently associated with autism, was less transmitted than expected (p < 0.03), supporting a functional role for this variant. These findings suggest the need for further investigation of the role of GRIK2 in OCD.
多项证据表明，强迫症（OCD）可能是谷氨酸能功能障碍的结果。我们对156例患者和141例对照进行了病例对照研究，并对124个亲子三联体进行了传递不平衡检验，以寻找强迫症与两种海人酸受体GRIK2和GRIK3之间的关联。利用GRIK2中的三个单核苷酸多态性（SNP）和GRIK3中的一个SNP，我们在病例对照分析或基于家系的分析中未发现关联证据。只有最近与自闭症相关的GRIK2 SNP I867的传递低于预期（p < 0.03），这支持了该变体的功能作用。这些发现表明需要进一步研究GRIK2在强迫症中的作用。
