Moore Kateri A, Lemischka Ihor R
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Cell. 2004 Jul 23;118(2):139-40. doi: 10.1016/j.cell.2004.07.006.
Interaction of hematopoietic stem cells (HSCs) with their particular microenvironment, or niche, is critical for adult hematopoiesis in the bone marrow (BM). Arai et al. (this issue of Cell) demonstrate that HSCs that express the receptor tyrosine kinase Tie2 are quiescent. Ang-1, the ligand for Tie2, enhanced the ability of HSCs to become quiescent and also induced their adhesion to bone, protecting them from stresses that suppress hematopoiesis. These data suggest that the Ang-1/Tie2 signaling pathway plays a crucial role in the maintenance of HSCs in a quiescent state in the BM niche.
造血干细胞（HSCs）与其特定的微环境或壁龛之间的相互作用，对于骨髓（BM）中的成体造血至关重要。新井等人（本期《细胞》杂志）证明，表达受体酪氨酸激酶Tie2的造血干细胞处于静止状态。Tie2的配体血管生成素-1（Ang-1）增强了造血干细胞进入静止状态的能力，还诱导它们黏附于骨骼，保护它们免受抑制造血的应激影响。这些数据表明，Ang-1/Tie2信号通路在维持造血干细胞于骨髓壁龛中的静止状态方面起着关键作用。
