骨免疫学：骨骼与免疫系统的相互作用
Osteoimmunology: interactions of the bone and immune system.
作者信息
Lorenzo Joseph, Horowitz Mark, Choi Yongwon
机构信息
Department of Medicine, The University of Connecticut Health Center, N4054, MC5456, 263 Farmington Avenue, Farmington, Connecticut 06030-5456, USA.
出版信息
Endocr Rev. 2008 Jun;29(4):403-40. doi: 10.1210/er.2007-0038. Epub 2008 May 1.
Abstract
Bone and the immune system are both complex tissues that respectively regulate the skeleton and the body's response to invading pathogens. It has now become clear that these organ systems often interact in their function. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. Because these two disciplines developed independently, investigators in each don't always fully appreciate the significance that the other system has on the function of the tissue they are studying. This review is meant to provide a broad overview of the many ways that bone and immune cells interact so that a better understanding of the role that each plays in the development and function of the other can develop. It is hoped that an appreciation of the interactions of these two organ systems will lead to better therapeutics for diseases that affect either or both.
摘要
骨骼和免疫系统都是复杂的组织，分别调节骨骼以及身体对入侵病原体的反应。现在已经清楚的是，这些器官系统在功能上常常相互作用。这在骨髓中免疫细胞的发育以及骨细胞在健康和疾病状态下的功能方面尤其如此。由于这两个学科是独立发展的，每个学科的研究人员并不总是充分认识到另一个系统对他们所研究组织功能的重要性。这篇综述旨在广泛概述骨骼和免疫细胞相互作用的多种方式，以便能更好地理解它们各自在对方的发育和功能中所起的作用。希望对这两个器官系统相互作用的认识能为影响其中一个或两个系统的疾病带来更好的治疗方法。
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