紫锥菊对小鼠高架十字迷宫焦虑模型的抗焦虑作用。

Anxiolytic effects of Echium amoenum on the elevated plus-maze model of anxiety in mice.

作者信息

Rabbani M, Sajjadi S E, Vaseghi G, Jafarian A

机构信息

Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Hezar Jerib Avenue, Isfahan, Iran.

出版信息

Fitoterapia. 2004 Jul;75(5):457-64. doi: 10.1016/j.fitote.2004.04.004.

DOI:10.1016/j.fitote.2004.04.004

PMID:15261383

Abstract

The ethanolic extract of Echium amoenum flowers at the dose of 50 mg/kg increased the percentage of time-spent and the percentage of arm entries in the open arms of the elevated plus-maze (EPM) and decreased the percentage of time-spent in the closed arms of EPM. Moreover, it prolonged the ketamine-induced latency to sleep but had no significant effects on total sleeping time induced by ketamine. Also, the locomotor activity was affected but not to the same extent as observed for diazepam. These results suggested that the extract of E. amoenum seems to possess anxiolytic effect with lower sedative activity than that of diazepam.

摘要

狭叶蓝蓟花乙醇提取物以50mg/kg的剂量给药，增加了高架十字迷宫（EPM）开放臂中停留时间的百分比和进入次数的百分比，并降低了EPM封闭臂中停留时间的百分比。此外，它延长了氯胺酮诱导的睡眠潜伏期，但对氯胺酮诱导的总睡眠时间没有显著影响。同时，运动活性受到影响，但程度与地西泮不同。这些结果表明，狭叶蓝蓟提取物似乎具有抗焦虑作用，且镇静活性低于地西泮。