来自白花丹的细胞毒性成分。

Cytotoxic constituents from Plumbago zeylanica.

作者信息

Nguyen A T, Malonne H, Duez P, Vanhaelen-Fastre R, Vanhaelen M, Fontaine J

机构信息

Laboratoire de Physiologie et de Pharmacologie Fondamentales, Institut de Pharmacie CP-205/7, Université Libre de Bruxelles, B-1050 Brussels, Belgium.

出版信息

Fitoterapia. 2004 Jul;75(5):500-4. doi: 10.1016/j.fitote.2004.03.009.

DOI:10.1016/j.fitote.2004.03.009

PMID:15261389

Abstract

The bioassay-guided fractionation of the dichloromethane extract of aerial parts of Plumbago zeylanica led to the isolation of beta-sitosterol, beta-sitosteryl-3beta-glucopyranoside, beta-sitosteryl-3beta-glucopyranoside-6'-O-palmitate (1), lupenone, lupeol acetate, plumbagin and trilinolein. Compound 1 showed cytotoxic activity against MCF7 and Bowes cancer cell lines (IC50 113 microM and 152 microM, respectively), beta-sitosterol inhibited Bowes cell growth (IC50 36.5 microM) and plumbagin was cytotoxic against MCF7 and Bowes cells (IC50 1.28 microM and 1.39 microM, respectively).

摘要

对白花丹地上部分二氯甲烷提取物进行生物测定导向的分离，得到了β-谷甾醇、β-谷甾醇-3β-葡萄糖苷、β-谷甾醇-3β-葡萄糖苷-6'-O-棕榈酸酯（1）、羽扇豆酮、羽扇豆醇乙酸酯、白花丹素和三亚麻酸甘油酯。化合物1对MCF7和鲍氏癌细胞系显示出细胞毒性活性（IC50分别为113微摩尔和152微摩尔），β-谷甾醇抑制鲍氏细胞生长（IC50为36.5微摩尔），白花丹素对MCF7和鲍氏细胞具有细胞毒性（IC50分别为1.28微摩尔和1.39微摩尔）。