1,3 - 二羟基 - 5 - （十三碳 - 4',7'- 二烯基）苯：一种来自软毛南美柴桂的新型细胞毒性化合物。

1,3-dihydroxy-5-(tridec-4',7'-dienyl)benzene: a new cytotoxic compound from Lithraea molleoides.

作者信息

López P, Ruffa M J, Cavallaro L, Campos R, Martino V, Ferraro G

机构信息

Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, 2 Piso, 1113 Buenos Aires, Argentina.

出版信息

Phytomedicine. 2005 Jan;12(1-2):108-11. doi: 10.1016/j.phymed.2003.07.013.

DOI:10.1016/j.phymed.2003.07.013

PMID:15693716

Abstract

A dichloromethane extract from the leaves of Lithraea molleoides (Anacardiaceae), an argentine medicinal plant, showed cytotoxicity on human hepatocellular carcinoma cell line. Bioassay guided fractionation of this extract led to the isolation of a new active 5-alkyl resorcinol: 1,3-dihydroxy-5-(tridec-4',7'-dienyl)benzene. Chemical structure was established based on spectroscopic data (UV, IR, MS, 1H-NMR, 13C-NMR, COSY). This compound presented cytotoxic activity on 3 human tumoral cell lines: hepatocellular carcinoma cell line-Hep G2 (IC50 +/- SD of 68 +/- 2 microM), mucoepidermoid pulmonary carcinoma cell line-H292 (IC50 +/- SD of 63 +/- 5 microM) and mammary gland adenocarcinoma cell line -MCF7 (IC50 +/- SD of 147 +/- 5).

摘要

阿根廷药用植物多花微花藤（漆树科）叶片的二氯甲烷提取物对人肝癌细胞系显示出细胞毒性。对该提取物进行生物测定导向的分级分离，得到一种新的活性5-烷基间苯二酚：1,3-二羟基-5-（十三碳-4',7'-二烯基）苯。根据光谱数据（紫外、红外、质谱、1H-核磁共振、13C-核磁共振、COSY）确定了化学结构。该化合物对3种人类肿瘤细胞系具有细胞毒性活性：肝癌细胞系-Hep G2（IC50±标准差为68±2微摩尔）、黏液表皮样肺癌细胞系-H292（IC50±标准差为63±5微摩尔）和乳腺腺癌细胞系-MCF7（IC50±标准差为147±5）。