毛叶黄牛木的细胞毒性成分。

Cytotoxic constituents from Cratoxylum arborescens.

作者信息

Pattanaprateeb Prasert, Ruangrungsi Nijsiri, Cordell Geoffrey A

机构信息

Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

出版信息

Planta Med. 2005 Feb;71(2):181-3. doi: 10.1055/s-2005-837788.

DOI:10.1055/s-2005-837788

PMID:15729629

Abstract

A new natural xanthone, 1,3-dihydroxy-6,7-dimethoxy-2,8-diprenylxanthone, together with four known compounds, fuscaxanthone C, 1,7-dihydroxyxanthone, 3-geranyloxy-6-methyl-1,8-dihydroxyanthraquinone and 2-geranylemodin were isolated from the stem bark of Cratoxylum arborescens (Vahl) Blume. The structure elucidations were achieved through spectroscopic analyses. Compounds 1 and 5 showed moderate activity against the human small cell lung cancer NCI-H187 cell line with the IC50 values of 3.69 +/- 1.27 microg/mL and 3.08 +/- 0.73 microg/mL, respectively.

摘要

从毛叶黄牛木（Cratoxylum arborescens (Vahl) Blume）的茎皮中分离出一种新的天然呫吨酮，即1,3 - 二羟基 - 6,7 - 二甲氧基 - 2,8 - 二异戊烯基呫吨酮，以及四种已知化合物，即fuscaxanthone C、1,7 - 二羟基呫吨酮、3 - 香叶氧基 - 6 - 甲基 - 1,8 - 二羟基蒽醌和2 - 香叶大黄素。通过光谱分析完成了结构解析。化合物1和5对人小细胞肺癌NCI - H187细胞系显示出中等活性，IC50值分别为3.69±1.27微克/毫升和3.08±0.73微克/毫升。