人类基因组中假基因的大规模分析。
Large-scale analysis of pseudogenes in the human genome.
作者信息
Zhang ZhaoLei, Gerstein Mark
机构信息
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520-8114, USA.
出版信息
Curr Opin Genet Dev. 2004 Aug;14(4):328-35. doi: 10.1016/j.gde.2004.06.003.
Pseudogenes are considered as genomic fossils: disabled copies of functional genes that were once active in the ancient genome. Recently, whole-genome computational approaches have revealed thousands of pseudogenes in the genomes of the human and other eukaryotes. Identification of these pseudogenes can improve the accuracy of gene annotation. It also offers new insight on the evolutionary history and the stability of the genome as a whole.
假基因被视为基因组化石
它们是功能基因的失活拷贝，这些功能基因曾在古代基因组中活跃。最近，全基因组计算方法已在人类和其他真核生物的基因组中发现了数千个假基因。这些假基因的识别可以提高基因注释的准确性。它还为整个基因组的进化历史和稳定性提供了新的见解。
Zotero 插件