口腔黏膜黑色素瘤：一系列病例报告

Oral mucosal melanoma: a series of case reports.

作者信息

Garzino-Demo Paolo, Fasolis Massimo, Maggiore Gian Marco La Terra, Pagano Marco, Berrone Sid

机构信息

Department of Maxillofacial Surgery, University of Turin, Italy.

出版信息

J Craniomaxillofac Surg. 2004 Aug;32(4):251-7. doi: 10.1016/j.jcms.2003.12.007.

DOI:10.1016/j.jcms.2003.12.007

PMID:15262258

Abstract

INTRODUCTION

Due to the rarity of oral malignant melanomas case reports are a necessary source of information. Ten new cases are reported with a minimum follow-up of 3 years.

PATIENTS AND METHODS

Patients were treated during a period of 10 years. Clinical, demographic and pathologic findings were examined.

RESULTS

In 6 males (60%) and 4 females with a mean age of 64.3 years the tumour locations were: hard palate-maxillary gingiva (3 cases), maxillary gingiva (2), lower gingiva (2), tongue (2), hard/soft palate-buccal mucosa (1). Pre-existing melanotic pigmentation had been present in 4 patients. Four patients were in stage I, 5 in stage II, and 1 in stage III. Surgical excision was the primary treatment in 9 cases. Five patients underwent simultaneous neck dissections. All patients received radiation and multimode adjuvant therapies. After a 3-year follow-up 3 patients are still alive (50% (2/4) of those presenting in stage I and 20% (1/5) in stage II).

CONCLUSIONS

Due to the rarity of oral melanoma, individual experience is limited. The poor prognosis and the different treatments reflect this situation.

摘要

引言

由于口腔恶性黑色素瘤较为罕见，病例报告是必要的信息来源。本文报告了10例新病例，最短随访时间为3年。

患者与方法

患者在10年期间接受治疗。对临床、人口统计学和病理结果进行了检查。

结果

6例男性（60%）和4例女性，平均年龄64.3岁，肿瘤部位分别为：硬腭-上颌牙龈（3例）、上颌牙龈（2例）、下牙龈（2例）、舌（2例）、硬/软腭-颊黏膜（1例）。4例患者术前存在黑色素沉着。4例患者为I期，5例为II期，1例为III期。9例患者的主要治疗方法为手术切除。5例患者同时接受了颈部清扫术。所有患者均接受了放疗和多模式辅助治疗。经过3年随访，3例患者仍存活（I期患者中50%（2/4）存活，II期患者中20%（1/5）存活）。