González-García Raúl, Naval-Gías Luis, Martos Pedro L, Nam-Cha Syong Hyun, Rodríguez-Campo Francisco J, Muñoz-Guerra Mario F, Sastre-Pérez Jesús
Servicio de Cirugía Oral y Maxilofacial, Hospital Universitario de La Princesa, Universidad Autónoma, Madrid.
Med Oral Patol Oral Cir Bucal. 2005 May-Jul;10(3):264-71.
The appearance of primary melanomas of the oral mucosa is uncommon. The aggressiveness of this entity and the absence of any standardized treatment protocol make the prognostic unfortunate. The difficulty to obtain free surgical margins, the elevated tendency to invade in depth and the early haematogenous metastasis have been referred as features which may explain its bad prognosis, even in comparison with cutaneous melanoma. However, no large clinical series exist and actually, clinical cases are the main source of information. Due to the absence of any treatment modality which may substantially increase long-term survival, we suggest the use of resective surgery with wide margins and early diagnosis by means of biopsy for suspicious melanotic-pigmented lesions. In this work we present 2 new cases of primary melanoma of the oral mucosa, with a follow-up period of 72 and 12 months respectively, and we make a review of the literature in relation with this rare entity.
口腔黏膜原发性黑色素瘤的表现并不常见。该疾病的侵袭性以及缺乏任何标准化治疗方案导致预后不佳。难以获得无瘤手术切缘、深度浸润倾向较高以及早期血行转移被认为是其预后不良的特征，即便与皮肤黑色素瘤相比也是如此。然而，目前尚无大型临床系列研究，实际上，临床病例是主要的信息来源。由于缺乏能显著提高长期生存率的治疗方式，我们建议采用切缘较宽的切除手术，并通过对可疑黑色素沉着病变进行活检实现早期诊断。在这项研究中，我们报告了2例口腔黏膜原发性黑色素瘤的新病例，随访期分别为72个月和12个月，并对有关这一罕见疾病的文献进行了综述。
