Rebuttal: adaptive point mutation (Rosenberg and Hastings).
作者信息
Roth John R, Andersson Dan I
机构信息
University of California Davis, Microbiology Section, One Shields Ave., Davis, CA 95616, USA.
出版信息
J Bacteriol. 2004 Aug;186(15):4844. doi: 10.1128/JB.186.15.4844.2004.
Abstract
摘要
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Amplification-mutagenesis--how growth under selection contributes to the origin of genetic diversity and explains the phenomenon of adaptive mutation.
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Adaptive mutation: general mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac.
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Evidence that selected amplification of a bacterial lac frameshift allele stimulates Lac(+) reversion (adaptive mutation) with or without general hypermutability.
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