Cheng Jin-wei, Ma Xiao-ye, Wei Rui-li
Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Chin Med J (Engl). 2004 Jul;117(7):1006-10.
Non-penetrating trabecular surgery is a new filtrating surgery without opening in ternal trabecular structures. This study was to estimate the overall efficacy of non-penetrating trabecular surgery for open angle glaucoma.
The published articles selected for this study were obtained by a computerised Medline and China Biological Medicine Disk search of the literature and a manual search of the bibliographies of relevant articles. Articles meeting the inclusion criteria were reviewed systematically, and the reported data were aggregated using the statistical techniques of meta-analysis.
A total of 37 articles were included in the meta-analysis. The pooled complete success rates of non-penetrating trabecular surgery with different techniques were: deep sclerectomy single, 69.7% (95% CI: 58.5% - 81.0%); deep sclerectomy with collagen implant, 59.4% (95% CI: 47.0% - 71.8%); deep sclerectomy with reticulated hyaluronic acid implant, 71.1% (95% CI: 56.8% - 85.3%); and viscocanalostomy, 72.0% (95% CI: 57.6% - 86.4%). The overall weighted complete success rate of non-penetrating trabecular surgery was 67.8% (95% CI: 61.4% - 74.3%).
Non-penetrating trabecular surgery is the best available therapy method for medically uncontrolled open angle glaucoma with a complete success rate of over 60%. But the different techniques cannot belie the complete success rate of non-penetrating trabecular surgery.
非穿透性小梁手术是一种不切开内部小梁结构的新型滤过性手术。本研究旨在评估非穿透性小梁手术治疗开角型青光眼的总体疗效。
本研究所选的已发表文章通过计算机检索Medline和中国生物医学文献数据库，并人工检索相关文章的参考文献获得。对符合纳入标准的文章进行系统评价，并使用Meta分析的统计技术汇总报告的数据。
Meta分析共纳入37篇文章。不同技术的非穿透性小梁手术的合并完全成功率分别为：单纯深层巩膜切除术，69.7%（95%CI：58.5% - 81.0%）；胶原植入物深层巩膜切除术，59.4%（95%CI：47.0% - 71.8%）；网状透明质酸植入物深层巩膜切除术，71.1%（95%CI：56.8% - 85.3%）；粘小管成形术，72.0%（95%CI：57.6% - 86.4%）。非穿透性小梁手术的总体加权完全成功率为67.8%（95%CI：61.4% - 74.3%）。
非穿透性小梁手术是药物治疗无法控制的开角型青光眼的最佳治疗方法，完全成功率超过60%。但不同技术对非穿透性小梁手术的完全成功率并无显著影响。
