染色体浓缩：实时DNA压缩

Chromosome condensation: DNA compaction in real time.

作者信息

Porter Iain M, Khoudoli Guennadi A, Swedlow Jason R

机构信息

Division of Gene Regulation and Expression, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.

出版信息

Curr Biol. 2004 Jul 27;14(14):R554-6. doi: 10.1016/j.cub.2004.07.009.

DOI:10.1016/j.cub.2004.07.009

PMID:15268872

Abstract

Mitotic chromosomes must be organised into a highly ordered and compacted form to allow proper segregation of DNA during each round of cell division. Two new studies report observations of DNA compaction by eukaryotic and bacterial condensin molecules in real time using magnetic and optical trapping micromanipulation techniques.

摘要

有丝分裂染色体必须被组织成高度有序且紧密的形式，以便在每一轮细胞分裂过程中实现DNA的正确分离。两项新研究报告了利用磁性和光学捕获微操纵技术实时观察真核生物和细菌凝缩蛋白分子对DNA的压缩情况。