Goldacre M J, Duncan M E, Cook-Mozaffari P, Neil H A W
Unit of Health-Care Epidemiology, University of Oxford, Old Road, Oxford, UK.
Diabet Med. 2004 Aug;21(8):936-9. doi: 10.1111/j.1464-5491.2004.01226.x.
Mortality statistics have customarily been coded and analysed using only one underlying cause of death. Rules for selecting the underlying cause, when more than one cause is certified on a death certificate, have changed twice in England over the past 20 years. We used data from death certificates for 1979-99 to compare mortality rates for diabetes mellitus certified anywhere on death certificates with those certified as the underlying cause.
Analysis of data from 18,917 death certificates that included diabetes mellitus in the former Oxford health region.
Based on the underlying cause of death, mortality rates for diabetes varied substantially between the periods defined by rule changes. Based on mentions of diabetes anywhere on the death record, mortality rates were almost unchanged over time: they showed a non-significant rise of 0.1% per year (95% confidence interval -0.3, 0.6). Circulatory diseases were certified causes of death in 71% of all deaths in people with diabetes. Although mortality rates from circulatory diseases in the general population fell by 2.5% per year, rates for circulatory diseases in combination with diabetes did not fall.
Two explanations are possible for the lack of change in mortality rates for diabetes based on all certified mentions between 1979 and 1999. Increasing prevalence and improved survival may have resulted in no net change; and/or there may have been no improvement in survival for people whose diabetes is associated with life-threatening pathology and in particular with circulatory diseases.
死亡率统计通常仅使用一个根本死因进行编码和分析。在过去20年中,当死亡证明上认证了不止一个死因时,选择根本死因的规则在英国已更改了两次。我们使用1979 - 1999年死亡证明的数据,比较在死亡证明上任何位置认证的糖尿病死亡率与认证为根本死因的糖尿病死亡率。
对前牛津健康地区18917份包含糖尿病的死亡证明数据进行分析。
基于根本死因,糖尿病死亡率在由规则变化定义的不同时期之间有很大差异。基于死亡记录上任何位置提及糖尿病,死亡率随时间几乎没有变化:每年显示出0.1%的非显著上升(95%置信区间 -0.3,0.6)。循环系统疾病在所有糖尿病患者死亡中被认证为死因的占71%。尽管普通人群中循环系统疾病的死亡率每年下降2.5%,但与糖尿病合并的循环系统疾病死亡率并未下降。
对于1979年至1999年间基于所有认证提及的糖尿病死亡率缺乏变化,有两种可能的解释。患病率上升和生存率提高可能导致没有净变化;和/或与危及生命的病理状况尤其是循环系统疾病相关的糖尿病患者的生存率可能没有改善。