Zullo Angelo, Romiti Adriana, Borrini Francesco, Hassan Cesare, Stella Francesca, Sarcina Ida, Martini Maria Enrica, Tomao Silverio, Morini Sergio, Mingazzini Pietro
Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
Anticancer Res. 2004 May-Jun;24(3a):1603-7.
Although E-cadherins have been involved in gastric carcinogenesis, their role in precancerous lesions, such as intestinal metaplasia, is still unclear. This study aimed to assess the role of both intestinal metaplasia and H. pylori infection on E-cadherin expression in gastric mucosa.
Twenty-one consecutive patients with intestinal metaplasia were enrolled to assess E-cadherin expression in metaplastic areas. Twenty further patients without intestinal metaplasia, with and without H. pylori, were enrolled to evaluate the role of the infection on E-cadherin expression. All patients underwent upper endoscopy and gastric biopsies were taken for histological and immunohistochemical assessment.
A substantial reduction of E-cadherin expression in metaplastic areas was observed in 14 (67%) of the 21 patients, similarly in H. pylori-infected and uninfected patients (64% vs 71%, p=0.3). In the group without intestinal metaplasia, no reduction in E-cadherin expression was detected either in infected patients or in those without H. pylori infection.
The data showed that intestinal metaplasia is associated with E-cadherin down-regulation, whereas H. pylori infection does not seem to play a direct role in this process.
尽管E-钙黏蛋白参与了胃癌的发生发展，但其在癌前病变如肠化生中的作用仍不清楚。本研究旨在评估肠化生和幽门螺杆菌感染对胃黏膜中E-钙黏蛋白表达的作用。
连续纳入21例肠化生患者，以评估化生区域中E-钙黏蛋白的表达。另外纳入20例无肠化生的患者，其中有幽门螺杆菌感染和无幽门螺杆菌感染的各10例，以评估感染对E-钙黏蛋白表达的作用。所有患者均接受上消化道内镜检查，并取胃组织活检进行组织学和免疫组化评估。
21例患者中有14例（67%）化生区域的E-钙黏蛋白表达显著降低，幽门螺杆菌感染患者和未感染患者情况相似（64%对71%，p=0.3）。在无肠化生的组中，无论是感染患者还是未感染幽门螺杆菌的患者，均未检测到E-钙黏蛋白表达降低。
数据表明，肠化生与E-钙黏蛋白下调有关，而幽门螺杆菌感染似乎在这一过程中不发挥直接作用。
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