Tsujitani Shunichi, Saito Hiroaki, Maeta Yoshihiko, Yamaguchi Kenichi, Tatebe Shigeru, Kondo Akira, Kaibara Nobuaki
Department of Surgery, Faculty of Medicine, Tottori University, Yonago, Japan.
Anticancer Res. 2004 May-Jun;24(3b):1853-9.
We investigated the prognostic significance of microvessel density and the relationship between the expression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP), and angiogenesis in patients with gastric carcinoma.
The expression of VEGF and TP, and the microvessel density were examined by immunohistochemistry in patients with gastric carcinoma invading the serosa.
The prognosis of patients with low microvessel density in the cancerous tissue was significantly better than that of patients with high microvessel density. A multivariate analysis showed that microvessel density, lymph node metastasis and tumor size were independent prognostic indicators. VEGF was expressed in tumor cells and TP was expressed in both tumor cells and infiltrating cells. VEGF expression in tumor cells and TP expression in infiltrating cells significantly correlated with microvessel density. However, microvessel density was not correlated with TP expression in tumor cells. Combined analysis based on VEGF expression in tumor cells and TP expression in infiltrating cells revealed that microvessel density was the highest in VEGF-positive and TP-positive tumors and the lowest in VEGF-negative and TP-negative tumors. Microvessel density is an independent prognostic indicator in patients with gastric carcinoma invading the serosa.
VEGF expression in tumor cells and TP expression in infiltrating cells may indicate the microvessel density.
我们研究了微血管密度的预后意义，以及血管内皮生长因子（VEGF）和胸苷磷酸化酶（TP）的表达与胃癌患者血管生成之间的关系。
采用免疫组织化学方法检测侵犯浆膜的胃癌患者VEGF和TP的表达以及微血管密度。
癌组织中微血管密度低的患者预后明显好于微血管密度高的患者。多因素分析显示，微血管密度、淋巴结转移和肿瘤大小是独立的预后指标。VEGF在肿瘤细胞中表达，TP在肿瘤细胞和浸润细胞中均有表达。肿瘤细胞中的VEGF表达和浸润细胞中的TP表达与微血管密度显著相关。然而，微血管密度与肿瘤细胞中的TP表达无关。基于肿瘤细胞中VEGF表达和浸润细胞中TP表达的联合分析显示，VEGF阳性和TP阳性肿瘤的微血管密度最高，VEGF阴性和TP阴性肿瘤的微血管密度最低。微血管密度是侵犯浆膜的胃癌患者的独立预后指标。
肿瘤细胞中的VEGF表达和浸润细胞中的TP表达可能提示微血管密度。
