Hussein M R
Department of Pathology, Assiut University Hospitals, Egypt.
J Clin Pathol. 2004 Aug;57(8):797-801. doi: 10.1136/jcp.2003.015800.
The incidence of cutaneous malignant melanomas is growing faster than that of any other cancer and therefore posing a major heath threat worldwide. In melanocytic skin tumours, the feasibility of correlating a specific pathological stage with a corresponding genetic alteration provides a remarkable opportunity to study the multistep tumorigenesis model. This multistep melanoma tumorigenesis is best described as a continuum of transformation of the melanocytes, melanocytic dysplasia, and melanoma formation. These steps involve genotypic alterations including loss of tumour suppressor genes, microsatellite instability, and alterations of the mismatch repair system. This review seeks to examine melanoma tumorigenesis based on these genetic changes.
皮肤恶性黑色素瘤的发病率增长速度比其他任何癌症都要快，因此在全球范围内构成了重大的健康威胁。在黑素细胞性皮肤肿瘤中，将特定病理阶段与相应基因改变相关联的可行性为研究多步骤肿瘤发生模型提供了一个难得的机会。这种多步骤黑色素瘤肿瘤发生过程最好被描述为黑素细胞转化、黑素细胞发育异常和黑色素瘤形成的连续过程。这些步骤涉及基因型改变，包括肿瘤抑制基因的缺失、微卫星不稳定性以及错配修复系统的改变。本综述旨在基于这些基因变化来研究黑色素瘤的肿瘤发生过程。
