孤立肢体灌注作为一种模型来测试治疗转移性黑色素瘤的新药物。
Isolated limb infusion as a model to test new agents to treat metastatic melanoma.
机构信息
Department of Surgery, Duke University Medical Center, Durham, North Carolina.
出版信息
J Surg Oncol. 2014 Mar;109(4):357-65. doi: 10.1002/jso.23502. Epub 2013 Nov 20.
Abstract
The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic strategies. This review will focus on regional therapy for in-transit melanoma as a platform to investigate novel therapeutic approaches to improve regional disease control, and help us develop insights to more rationally design systemic therapy trials.
摘要
由于易于获取组织活检进行相关研究，并且可以使用临床前动物模型来验证新的治疗策略，因此转移疾病的肢体模型可以扩展我们对治疗黑色素瘤的理解。这篇综述将重点介绍转移中黑色素瘤的区域治疗，作为一种平台来研究改善区域疾病控制的新治疗方法，并帮助我们深入了解如何更合理地设计全身治疗试验。
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2
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J Clin Invest. 2013 Sep;123(9):3925-40. doi: 10.1172/JCI65745. Epub 2013 Aug 8.
3
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