Shivaram S, Crist K A, Chaudhuri B, Mucci S J, Chaudhuri P K
Department of Surgery, Medical College of Ohio, Toledo 43614.
J Surg Res. 1992 Sep;53(3):234-7. doi: 10.1016/0022-4804(92)90040-7.
Cholecystokinin (CCK) exerts an influential effect on the growth of normal pancreas. It is postulated that carcinoma arising from the pancreas may retain some normal pancreatic properties as far as hormone dependency is concerned. In an effort to examine the effect of CCK on the growth of pancreatic cancer, we evaluated the effect of CCK receptor antagonist on the growth of a transplantable adenocarcinoma of the pancreas. For this study we utilized three groups of hamsters with adenocarcinoma of the pancreas transplanted subcutaneously on the right flank. Group I (n = 15) served as control. Group II (n = 15) received CCK receptor antagonist (L-364,718), 0.1 mg/100 g body wt subcutaneously BID. Group III received CCK receptor antagonist in the same dose but treatment was started after tumors became palpable. All animals were examined daily. Latency for tumor growth, tumor size, and body weight were recorded. Animals were sacrificed after 3 weeks and final tumor volume and weight were measured. CCK receptor antagonist (L-364,718) significantly reduced pancreatic carcinoma growth when given immediately after transplantation and also in animals with established tumor. However, this inhibitory effect of L-364,718 was only partial and effective only for a brief time. This finding suggests CCK may have only a minimal influence on the biologic behavior of exocrine pancreatic cancer.
胆囊收缩素（CCK）对正常胰腺的生长具有重要影响。据推测，就激素依赖性而言，胰腺产生的癌可能保留一些正常胰腺的特性。为了研究CCK对胰腺癌生长的影响，我们评估了CCK受体拮抗剂对可移植性胰腺腺癌生长的作用。在本研究中，我们使用了三组仓鼠，它们的右胁腹皮下移植了胰腺腺癌。第一组（n = 15）作为对照。第二组（n = 15）皮下注射CCK受体拮抗剂（L-364,718），剂量为0.1 mg/100 g体重，每日两次。第三组接受相同剂量的CCK受体拮抗剂，但在肿瘤可触及后开始治疗。每天对所有动物进行检查。记录肿瘤生长的潜伏期、肿瘤大小和体重。3周后处死动物，测量最终肿瘤体积和重量。CCK受体拮抗剂（L-364,718）在移植后立即给予以及在已形成肿瘤的动物中均显著降低了胰腺癌的生长。然而，L-364,718的这种抑制作用只是部分的，且仅在短时间内有效。这一发现表明CCK对外分泌性胰腺癌的生物学行为可能只有极小的影响。
