茎谷布酮A-E的合成及生物学评价
Synthesis and biological evaluation of caulibugulones A-E.
作者信息
Wipf Peter, Joo Beomjun, Nguyen Theresa, Lazo John S
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
出版信息
Org Biomol Chem. 2004 Aug 7;2(15):2173-4. doi: 10.1039/b408184f. Epub 2004 Jul 5.
DOI:10.1039/b408184f
PMID:15280951
Abstract
The marine bryozoan metabolites caulibugulone A-E were prepared from a readily available isoquinoline dione. These natural products were found to be potent and selective inhibitors of the dual specificity phosphatase Cdc25B.
摘要
海洋苔藓虫代谢产物考利布古隆A - E是由一种易于获得的异喹啉二酮制备而成。这些天然产物被发现是双特异性磷酸酶Cdc25B的强效和选择性抑制剂。
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