Wipf Peter, Joo Beomjun, Nguyen Theresa, Lazo John S
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Org Biomol Chem. 2004 Aug 7;2(15):2173-4. doi: 10.1039/b408184f. Epub 2004 Jul 5.
The marine bryozoan metabolites caulibugulone A-E were prepared from a readily available isoquinoline dione. These natural products were found to be potent and selective inhibitors of the dual specificity phosphatase Cdc25B.
海洋苔藓虫代谢产物考利布古隆A - E是由一种易于获得的异喹啉二酮制备而成。这些天然产物被发现是双特异性磷酸酶Cdc25B的强效和选择性抑制剂。
