Dzúrik R, Lajdová I, Spustová V, Opatrný K
Institute of Preventive and Clinical Medicine, Bratislava, Czechoslovakia.
Nephron. 1992;61(1):64-7. doi: 10.1159/000186836.
Pseudouridine (psi) is a unique nucleoside accumulated in the sera of renal failure (RF) patients. Surprisingly data on its excretion are lacking. To get an overview, the psi serum level and urinary excretion were investigated in 73 healthy subjects (C), 16 patients not on dialysis (ND) and 12 hemodialysis patients (D). It was found: (a) psi accumulates in the sera of both ND and D patients. An inverse power correlation fits best with the relationship between serum psi and the clearance of endogenous creatinine (CCr). The amount of psi filtered in glomeruli of ND patients increases while it remains practically unchanged in D patients. However, the psi filtration load of residual nephrons increases with the decreasing CCr as a consequence of its increased serum concentration. (b) Both psi net resorption and secretion have been found in C subjects. The increased psi resorption diminishes the necessary increase of psi urinary excretion both in ND and D patients. The increase of psi resorption is marked if calculated on residual nephrons. (c) The slightly decreased psi excretion excludes the participation of its increased synthesis in its accumulation in RF. It is concluded that psi accumulation in RF is caused by the impairment of its kidney excretion and the increased psi resorption participates markedly in its retention.
假尿苷（ψ）是一种在肾衰竭（RF）患者血清中蓄积的独特核苷。令人惊讶的是，关于其排泄的数据却很缺乏。为了对此有一个全面的了解，我们对73名健康受试者（C组）、16名未进行透析的患者（ND组）和12名血液透析患者（D组）的ψ血清水平和尿排泄情况进行了研究。结果发现：（a）ψ在ND组和D组患者的血清中均有蓄积。血清ψ与内生肌酐清除率（CCr）之间的关系最适合用负幂相关来描述。ND组患者肾小球滤过的ψ量增加，而D组患者的该量基本保持不变。然而，由于血清浓度升高，残余肾单位的ψ滤过负荷随CCr的降低而增加。（b）在C组受试者中发现了ψ的净重吸收和分泌。增加的ψ重吸收减少了ND组和D组患者尿中ψ排泄量的必要增加。如果按残余肾单位计算，ψ重吸收的增加很明显。（c）ψ排泄量略有下降排除了其合成增加参与RF患者体内蓄积的可能性。结论是，RF患者体内ψ的蓄积是由其肾脏排泄功能受损所致，且增加的ψ重吸收在很大程度上参与了其潴留过程。
