精神分裂症中的糖尿病、迟发性运动障碍、帕金森症及静坐不能：一项将1998年糖尿病医疗指南应用于抗精神病药物使用情况的回顾性研究
Diabetes, tardive dyskinesia, parkinsonism, and akathisia in schizophrenia: a retrospective study applying 1998 diabetes health care guidelines to antipsychotic use.
作者信息
Lévy Emmanuelle, Margolese Howard C, Annable Lawrence, Chouinard Guy
机构信息
Clinical Psychopharmacology Unit, McGill University Health Centre and Department of Psychiatry, McGill University, Montreal, Quebec.
出版信息
Can J Psychiatry. 2004 Jun;49(6):398-402. doi: 10.1177/070674370404900611.
BACKGROUND
This study examines the links among diabetes, tardive dyskinesia (TD), and other extrapyramidal symptoms (EPS) in schizophrenia outpatients treated with typical and atypical antipsychotics.
OBJECTIVES
Using a retrospective chart review, we compared 30 schizophrenia patients with diabetes mellitus (DM) with 30 schizophrenia patients, matched for age and sex, with no DM. We compared prevalence and severity of parkinsonism, akathisia, TD, dystonia, and antipsychotic type (that is, typical vs atypical).
RESULTS
We found no statistically significant differences between the DM group and the non-DM group prevalence and severity of EPS, including TD.
CONCLUSION
We did not find DM and TD association to be significant in the era of atypical antipsychotics, possibly because of their antidyskinetic effect.
背景
本研究探讨了在使用典型和非典型抗精神病药物治疗的精神分裂症门诊患者中，糖尿病、迟发性运动障碍（TD）及其他锥体外系症状（EPS）之间的联系。
目的
通过回顾性病历审查，我们将30例患有糖尿病（DM）的精神分裂症患者与30例年龄和性别相匹配的无DM的精神分裂症患者进行了比较。我们比较了帕金森症、静坐不能、TD、肌张力障碍的患病率和严重程度以及抗精神病药物类型（即典型与非典型）。
结果
我们发现DM组和非DM组之间，包括TD在内的EPS患病率和严重程度没有统计学上的显著差异。
结论
在非典型抗精神病药物时代，我们未发现DM与TD之间存在显著关联，这可能是由于它们的抗运动障碍作用。
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