Mehta Ashok K, Muschaweck Nicole M, Ticku Maharaj K
Department of Pharmacology, MC 7764, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio TX 78229-3900, USA.
Drug Alcohol Depend. 2004 Sep 6;75(3):323-5. doi: 10.1016/j.drugalcdep.2004.03.015.
We investigated the effect of ethanol on the binding of the gamma-hydroxybutyric acid (GHB) receptor ligand [3H]NCS-382 in the rat cerebral cortex and hippocampus. Ethanol (50-100 mM) did not alter the binding of [3H]NCS-382. Furthermore, acute (3g/kg, p.o.) as well as chronic (9-15 g/kg/day p.o. for 6 days) administration of ethanol also did not have any significant effect on the binding of [3H]NCS-382 in the rat cerebrocortical and hippocampal membranes. These observations suggest that ethanol does not interact directly with the GHB receptor in vitro or in vivo, and GHB receptor may not be involved in the pharmacological effects of ethanol.
我们研究了乙醇对大鼠大脑皮层和海马体中γ-羟基丁酸（GHB）受体配体[3H]NCS-382结合的影响。乙醇（50-100 mM）不会改变[3H]NCS-382的结合。此外，急性（3g/kg，口服）以及慢性（9-15 g/kg/天，口服，持续6天）给予乙醇对大鼠脑皮质和海马体膜中[3H]NCS-382的结合也没有任何显著影响。这些观察结果表明，乙醇在体外或体内均不直接与GHB受体相互作用，并且GHB受体可能不参与乙醇的药理作用。
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