Krischer S, Ott H, Barker M, Frank J, Erdmann S
Universitätskinderklinik der RWTH Aachen.
Klin Padiatr. 2004 Jul-Aug;216(4):236-7. doi: 10.1055/s-2004-820299.
Borreliosis is the most common vector transmitted disease in childhood. Although the disease manifests with an erythema migrans in 80 % of the patients, multilocular skin manifestations are only observed in 2-18 % of these. Differential diagnoses of erythema migrans include erysipelas, persistent insect bite reaction, and fixed drug eruption, in particular when the clinical history does not reveal a tick bite.
We report on a 5-year-old boy showing nine erythemas with central pallor on his face, trunk, arms and legs. He recalled a tick bite 3 weeks before.
Serological studies revealed an acute infection with Borrelia burgdorferi. After antibiotic treatment with orally administered amoxicillin skin manifestations resolved within three days. During a follow-up period of six months the patient revealed no signs of persistent borreliosis.
Multilocular erythema migrans is a possible manifestation of borreliosis and is classified as disseminated early infection which is frequently associated with systemic reactions, including malaise, arthritis, carditis, headache and even meningeal signs. Treatment is based on antibiotics, which should preferably be given intravenously in case of systemic signs.
莱姆病是儿童期最常见的媒介传播疾病。尽管80%的患者会出现游走性红斑,但其中仅有2% - 18%会出现多灶性皮肤表现。游走性红斑的鉴别诊断包括丹毒、持续性蚊虫叮咬反应和固定性药疹,尤其是在临床病史未显示有蜱叮咬的情况下。
我们报告一名5岁男孩,其面部、躯干、手臂和腿部出现9处中央苍白的红斑。他回忆3周前曾被蜱叮咬。
血清学研究显示急性伯氏疏螺旋体感染。口服阿莫西林进行抗生素治疗后,皮肤表现在三天内消退。在六个月的随访期内,患者未出现持续性莱姆病的迹象。
多灶性游走性红斑是莱姆病的一种可能表现,被归类为早期播散性感染,常伴有全身反应,包括不适、关节炎、心肌炎、头痛甚至脑膜刺激征。治疗以抗生素为主,出现全身症状时最好静脉给药。