通过静脉注射一种新型脂质包裹的超声造影剂增强兔肝脏和肾脏的灰度
Grey scale enhancement of rabbit liver and kidney by intravenous injection of a new lipid-coated ultrasound contrast agent.
作者信息
Liu Ping, Gao Yun-Hua, Tan Kai-Bin, Liu Zheng, Zuo Song
机构信息
Department of Ultrasound, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
出版信息
World J Gastroenterol. 2004 Aug 15;10(16):2369-72. doi: 10.3748/wjg.v10.i16.2369.
AIM
To assess the grey scale enhancement of a new lipid-coated ultrasound contrast agent in solid abdominal organs as liver and kidney.
METHODS
Size distribution and concentration of the lipid-coated contrast microbubbles were analyzed by a Coulter counter. Two-dimensional (2D) second harmonic imaging of the hepatic parenchyma, the inferior vena cava and the right kidney of the rabbits were acquired before and after contrast agent injection. Images were further quantified by histogram in Adobe Photoshop 6.0. Time-intensity curves of hepatic parenchyma, inferior vena cava and renal cortex were generated from the original grey scale.
RESULTS
The 2D images of hepatic parenchyma and cortex of the kidney were greatly enhanced after injection and the peak time could last more than 50 min.
CONCLUSION
This new lipid ultrasound contrast agent could significantly enhance the grey scale imaging of the hepatic parenchyma and the renal cortex for more than 50 min.
目的
评估一种新型脂质包裹超声造影剂在肝脏和肾脏等腹部实性器官中的灰阶增强效果。
方法
采用库尔特计数器分析脂质包裹微泡造影剂的大小分布和浓度。在注射造影剂前后获取兔肝脏实质、下腔静脉和右肾的二维（2D）二次谐波成像。图像在Adobe Photoshop 6.0中通过直方图进一步定量分析。从原始灰阶生成肝脏实质、下腔静脉和肾皮质的时间-强度曲线。
结果
注射后肝脏实质和肾皮质的二维图像显著增强，峰值时间可持续超过50分钟。
结论
这种新型脂质超声造影剂可使肝脏实质和肾皮质的灰阶成像显著增强，持续时间超过50分钟。
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