Bishop Kate N, Holmes Rebecca K, Sheehy Ann M, Malim Michael H
Department of Infectious Diseases, Guy's, King's and St. Thomas' School of Medicine, King's College London, London, SE1 9RT, UK.
Science. 2004 Jul 30;305(5684):645. doi: 10.1126/science.1100658.
Retroviral DNA can be subjected to cytosine-to-uracil editing through the action of members of the APOBEC family of cytidine deaminases. Here we demonstrate that APOBEC-mediated cytidine deamination of human immunodeficiency virus (HIV) virion RNA can also occur. We speculate that the natural substrates of the APOBEC enzymes may extend to RNA viruses that do not replicate through DNA intermediates. Thus, cytosine-to-uracil editing may contribute to the sequence diversification of many viruses.
逆转录病毒DNA可通过载脂蛋白B mRNA编辑酶催化多肽（APOBEC）家族胞苷脱氨酶成员的作用进行胞嘧啶到尿嘧啶的编辑。在此，我们证明了APOBEC介导的人类免疫缺陷病毒（HIV）病毒体RNA的胞苷脱氨作用也会发生。我们推测，APOBEC酶的天然底物可能扩展到不通过DNA中间体复制的RNA病毒。因此，胞嘧啶到尿嘧啶的编辑可能有助于许多病毒的序列多样化。
