急需：一种用于HIV-1疫苗研发流程的筛选工具。

Urgently needed: a filter for the HIV-1 vaccine pipeline.

作者信息

Moore John P, Burton Dennis R

机构信息

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA.

出版信息

Nat Med. 2004 Aug;10(8):769-71. doi: 10.1038/nm0804-769.

DOI:10.1038/nm0804-769

PMID:15286768

Abstract

Research groups worldwide are trying to make immunogens intended to elicit neutralizing antibody responses as part of a prophylactic vaccine to counter the spread of HIV-1. The relative merits of different designs can only be gauged properly through comparative studies, and particularly by evaluating human or animal antisera under identical, or comparable, conditions. Hence there is a need for assay standardization and for the creation of a centralized testing facility that could distribute consensus protocols and reagents.

摘要

世界各地的研究团队都在尝试制备免疫原，以引发中和抗体反应，作为预防艾滋病病毒1型传播的预防性疫苗的一部分。不同设计的相对优点只能通过比较研究来恰当评估，尤其是通过在相同或可比条件下评估人或动物抗血清。因此，需要进行检测标准化，并建立一个能够分发统一方案和试剂的集中检测机构。