酸奶对临界高血压男性血压影响的随机对照试验

Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men.

作者信息

Mizushima Shunsaku, Ohshige Kenji, Watanabe Junko, Kimura Maki, Kadowaki Takashi, Nakamura Yasunori, Tochikubo Osamu, Ueshima Hirotsugu

机构信息

International Research Center for Medical Education, The University of Tokyo, Tokyo, Japan.

出版信息

Am J Hypertens. 2004 Aug;17(8):701-6. doi: 10.1016/j.amjhyper.2004.03.674.

DOI:10.1016/j.amjhyper.2004.03.674

PMID:15288885

Abstract

BACKGROUND

A double-blind randomized controlled trial was carried out to assess the effect of sour milk, containing two tripeptides (valine-proline-proline and isoleucine-proline-proline), on blood pressure (BP).

METHODS

A total of 46 borderline hypertensive men aged 23 to 59 years were recruited at their workplace for this trial. Subjects were randomly allocated into two groups; sour milk drink group (S-group, n = 23) and placebo (acidified milk) drink group (P-group, n = 23) for 4 weeks. Blood pressure was measured twice at each occasion by a physician, at the health center of the company, with a mercury at baseline, 2 and 4 weeks. Statistical analysis was performed by SPSS 10.0J.

RESULTS

The S-group and P-group showed no significant difference in baseline systolic BP (mean [SD], S: 147.6 [9.6], P: 145.3 [13.0]) or diastolic BP (S: 95.3 [9.9], P: 91.5 [9.6]). In the S-group, change in systolic BP at 2 and 4 weeks were -4.3 mm Hg (95% confidence interval [CI] -8.3 to -0.4; P = .032) and -5.2 mm Hg (95% CI -10.1 to -0.3; P = .039), both statistically significant. Diastolic BP showed change from -1.7 mm Hg (95% CI -5.4 to 2.0) at 2 weeks and -2.0 (95% CI -5.4 to 1.5) at 4 weeks, respectively. In the P-group, change in systolic BP were -0.5 (95% CI -5.8 to 4.8) at 2 weeks and -3.7 (95% CI -8.3 to 0.9) and change in diastolic BP were -0.6 (95% CI -4.7 to 3.6) and -0.3 (95% CI -3.9 to 3.3), which were not statistically significant.

CONCLUSIONS

This trial demonstrated the beneficial effect of sour milk on BP in borderline hypertensive men who were not taking antihypertensive medication.

摘要

背景

开展了一项双盲随机对照试验，以评估含有两种三肽（缬氨酸 - 脯氨酸 - 脯氨酸和异亮氨酸 - 脯氨酸 - 脯氨酸）的酸奶对血压（BP）的影响。

方法

在工作场所招募了46名年龄在23至59岁之间的临界高血压男性参与本试验。受试者被随机分为两组；酸奶饮料组（S组，n = 23）和安慰剂（酸化牛奶）饮料组（P组，n = 23），为期4周。由医生在公司健康中心，使用汞柱血压计在基线、第2周和第4周各测量两次血压。采用SPSS 10.0J进行统计分析。

结果

S组和P组在基线收缩压（均值[标准差]，S组：147.6[9.6]，P组：145.3[13.0]）或舒张压（S组：95.3[9.9]，P组：91.5[9.6]）方面无显著差异。在S组中，第2周和第4周收缩压的变化分别为-4.3 mmHg（95%置信区间[CI]-8.3至-0.4；P = 0.032）和-5.2 mmHg（95% CI -10.1至-0.3；P = 0.039），均具有统计学意义。舒张压在第2周和第4周的变化分别为-1.7 mmHg（95% CI -5.4至2.0）和-2.0（95% CI -5.4至1.5）。在P组中，第2周收缩压变化为-0.5（95% CI -5.8至4.8），第4周为-3.7（95% CI -8.3至0.9）；舒张压变化分别为-0.6（95% CI -4.7至3.6）和-0.3（95% CI -3.9至3.3），均无统计学意义。