Lim Sang-Dong, Lee Kyungwon, Han Taewon, Jhun Hyunjhung, Han Ah-Ram, Hwang Yongjin, Hong Sangpil
Korea Food Research Institute, Wanju 55365, Korea.
Novalacto Co., Ltd., Daejeon 34016, Korea.
Food Sci Anim Resour. 2024 Jan;44(1):178-188. doi: 10.5851/kosfa.2023.e70. Epub 2024 Jan 1.
The aim of this study is to investigate whether milk fermented by K79, which exhibits angiotensin-converting enzyme inhibitory activity, has an effect on lowering the blood pressure of hypertensive rats and to investigate biomarker changes in their blood. Experimental group: normal group (NG, Wistar-Kyoto rats): distilled water, control group [NCG, spontaneously hypertensive rats (SHR)]: distilled water, high treatment group (HTG, SHR): 500 mg/kg/day, medium treatment group (SHR): 335 mg/kg/day, low treatment group (SHR): 170 mg/kg/day, positive control group (PCG, SHR): Enalapril, 10 mg/kg/day. The experimental animals used in this study were divided into groups composed of 8 animals. In terms of weight change, a significant difference was observed between the NG and the SHR group, but there was no significant difference between the SHR group. After 8 wk of feeding, blood pressure was lowered more significantly in the HTG (209.9±13.3 mmHg) than in the NCG (230.8±7.3 mmHg). The treatment group has an effect of lowering blood pressure by significantly suppressing blood pressure-related biomarker protein expression than NG. The results obtained can be used as an antihypertensive material in a variety of food raw materials.
本研究的目的是调查具有血管紧张素转换酶抑制活性的K79发酵乳是否对降低高血压大鼠的血压有影响，并调查其血液中生物标志物的变化。实验组：正常组（NG，Wistar-Kyoto大鼠）：蒸馏水，对照组[NCG，自发性高血压大鼠（SHR）]：蒸馏水，高剂量治疗组（HTG，SHR）：500毫克/千克/天，中剂量治疗组（SHR）：335毫克/千克/天，低剂量治疗组（SHR）：170毫克/千克/天，阳性对照组（PCG，SHR）：依那普利，10毫克/千克/天。本研究中使用的实验动物分为每组8只动物的组。在体重变化方面，NG组和SHR组之间观察到显著差异，但SHR组之间没有显著差异。喂养8周后，HTG组（209.9±13.3毫米汞柱）的血压降低比NCG组（230.8±7.3毫米汞柱）更显著。治疗组通过显著抑制与血压相关的生物标志物蛋白表达，具有降低血压的作用。所获得的结果可作为多种食品原料中的抗高血压物质。
