Georgakoudi Irene, Solban Nicolas, Novak John, Rice William L, Wei Xunbin, Hasan Tayyaba, Lin Charles P
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom Street, BHX630, Boston, MA 02114, USA.
Cancer Res. 2004 Aug 1;64(15):5044-7. doi: 10.1158/0008-5472.CAN-04-1058.
The fate of circulating tumor cells is an important determinant of their ability to form distant metastasis. Here, we demonstrate the use of in vivo flow cytometry as a powerful new method for detecting quantitatively circulating cancer cells. We specifically examine the circulation kinetics of two prostate cancer cell lines with different metastatic potential in mice and rats. We find that the cell line and the host environment affect the circulation kinetics of prostate cancer cells, with the intrinsic cell line properties determining the initial rate of cell depletion from the circulation and the host affecting cell circulation at later time points.
循环肿瘤细胞的命运是其形成远处转移能力的一个重要决定因素。在此，我们展示了体内流式细胞术作为一种强大的新方法用于定量检测循环癌细胞。我们专门研究了两种具有不同转移潜能的前列腺癌细胞系在小鼠和大鼠体内的循环动力学。我们发现细胞系和宿主环境会影响前列腺癌细胞的循环动力学，其中细胞系的内在特性决定了细胞从循环中清除的初始速率，而宿主则在后续时间点影响细胞循环。
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