Thomas Roman K, Wickenhauser Claudia, Kube Dieter, Tesch Hans, Diehl Volker, Wolf Jürgen, Vockerodt Martina
Molecular Tumor Biology and Tumor Immunology, Department I for Internal Medicine, University of Cologne, 50924 Cologne, Germany.
Leuk Lymphoma. 2004 May;45(5):1065-9. doi: 10.1080/10428190310001643421.
Classical Hodgkin's lymphoma (cHL) and B-cell Non-Hodgkin Lymphoma (B-NHL) occasionally occur in the same patient. However, molecular studies that aim at determining the clonal relationship between both lymphomas are rare. In most instances, the lymphoma components appear to be derived from the same germinal center (GC) B cell precursor. We describe the molecular monitoring of repeated clonal relapses in a patient with cHL in whom diffuse large B cell NHL (DLBCL) developed concurrently. Intriguingly, both lymphomas were clonally unrelated. Thus, the derivation from a shared precursor likely is not a general rule in cHL and DLBCL arising in the same patient.
经典型霍奇金淋巴瘤（cHL）和B细胞非霍奇金淋巴瘤（B-NHL）偶尔会出现在同一患者身上。然而，旨在确定这两种淋巴瘤之间克隆关系的分子研究却很少见。在大多数情况下，淋巴瘤成分似乎源自同一个生发中心（GC）B细胞前体。我们描述了对一名cHL患者反复克隆性复发的分子监测情况，该患者同时发生了弥漫性大B细胞NHL（DLBCL）。有趣的是，这两种淋巴瘤在克隆上并无关联。因此，源自共同前体这一情况在同一患者身上发生的cHL和DLBCL中可能并非普遍规律。
