复合性t(14;18)阴性滤泡性淋巴瘤和结节性淋巴细胞为主型霍奇金淋巴瘤
Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma.
作者信息
O'Neill John Patrick, Quinn Fiona, Dowling Anita, Walker Jan, Hayes Triona, Bird Brian, Flavin Richard
机构信息
St. James's Hospital, Dublin, Ireland.
Bons Secours Hospital, Cork, Ireland.
出版信息
Case Rep Hematol. 2018 Aug 2;2018:4312594. doi: 10.1155/2018/4312594. eCollection 2018.
A composite lymphoma is the rare simultaneous occurrence of two or more distinct lymphomas within a single tissue or organ. Herein, we describe a case of a 51-year-old man presenting with a history of lower limb rash, fatigue, and bulky abdominopelvic lymphadenopathy. An excisional left iliac lymph node biopsy was notable for the composite presence of two distinct lymphoid neoplasms, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), and follicular lymphoma (FL). Multiplex PCR and FISH analyses failed to demonstrate a t(14;18)(q32;q21) translocation in either composite lymphoma component. A clonal light-chain kappa (V/JC intron-kde) gene rearrangement was detected in the FL component only.
复合淋巴瘤是指在单个组织或器官中罕见地同时出现两种或更多种不同的淋巴瘤。在此，我们描述一例51岁男性病例，该患者有下肢皮疹、疲劳及腹部盆腔巨大淋巴结病病史。左侧髂淋巴结切除活检显示存在两种不同的淋巴样肿瘤，即结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHL）和滤泡性淋巴瘤（FL），此为复合表现。多重聚合酶链反应（PCR）和荧光原位杂交（FISH）分析未能在任何一种复合淋巴瘤成分中证实t(14;18)(q32;q21)易位。仅在FL成分中检测到克隆性轻链κ（V/JC内含子-kde）基因重排。
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