Tennese Alysa, Skrabek Pamela J, Nasr Michel R, Sekiguchi Debora R, Morales Carmen, Brown Theresa C, Weisenburger Dennis D, Perry Anamarija M
1 University of Manitoba, Winnipeg, MB, Canada.
2 City of Hope National Medical Center, Duarte, CA, USA.
Int J Surg Pathol. 2017 May;25(3):276-280. doi: 10.1177/1066896916671195. Epub 2016 Sep 29.
Composite lymphomas consist of 2 or more distinct lymphomas occurring in a single anatomical site or simultaneously in different sites and can be composed of any combination of B-cell non-Hodgkin lymphoma (NHL), T-cell NHL, or Hodgkin lymphoma (HL). Cases of composite lymphomas with more than 2 lymphomas are extremely rare, with only 4 reports in the literature. We report the case of a 49-year-old man with a triple composite lymphoma in a single lymph node, consisting of small lymphocytic lymphoma, follicular lymphoma, and mantle cell lymphoma in situ. The patient received multiple courses of chemotherapy and an autologous stem cell transplant, which resulted in complete remission. Then, 6 years after the stem cell transplant, he developed classical HL. This unique case is, to our knowledge, the first report of a patient with triple composite lymphoma consisting of 3 small mature B-cell NHLs, who subsequently developed a fourth lymphoma.
复合淋巴瘤由发生在单个解剖部位或同时发生在不同部位的2种或更多种不同淋巴瘤组成，可由B细胞非霍奇金淋巴瘤（NHL）、T细胞NHL或霍奇金淋巴瘤（HL）的任何组合构成。具有2种以上淋巴瘤的复合淋巴瘤病例极为罕见，文献中仅有4例报道。我们报告1例49岁男性，其单个淋巴结发生三重复合淋巴瘤，由小淋巴细胞淋巴瘤、滤泡性淋巴瘤和原位套细胞淋巴瘤组成。该患者接受了多疗程化疗及自体干细胞移植，结果达到完全缓解。然后，在干细胞移植6年后，他发生了经典型HL。据我们所知，这一独特病例是首例关于由3种小成熟B细胞NHL组成的三重复合淋巴瘤患者随后发生第四种淋巴瘤的报道。
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