Siddiqui Rina, Onel Kenan, Facio Flavia, Offit Kenneth
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Curr Oncol Rep. 2004 Sep;6(5):380-7. doi: 10.1007/s11912-004-0064-8.
Whereas familial clustering of malignant lymphoma is well documented, the molecular changes underlying familial lymphoma syndromes remain unclear. An understanding of the hereditary basis of lymphoma may lead to the identification of new molecular markers for disease or novel therapeutic targets. This paper reviews the genetics of familial lymphoma, focusing on germline susceptibilities to lymphoma as well as germline susceptibilities to environmental exposures that have been linked to lymphoma.
虽然恶性淋巴瘤的家族聚集现象已有充分记录，但家族性淋巴瘤综合征背后的分子变化仍不清楚。了解淋巴瘤的遗传基础可能会导致识别出新的疾病分子标志物或新的治疗靶点。本文综述了家族性淋巴瘤的遗传学，重点关注淋巴瘤的种系易感性以及与淋巴瘤相关的环境暴露的种系易感性。
