Kashani-Sabet Mohammed
Averback Melanoma Laboratory, University of California at San Francisco Cancer Center, 1600 Divisadero Street, Second Floor, Box 1706, San Francisco, CA 94115, USA.
Curr Oncol Rep. 2004 Sep;6(5):401-5. doi: 10.1007/s11912-004-0067-5.
Sophisticated molecular techniques that have recently become available permit analysis of genome-wide changes in gene copy number (DNA) or expression (RNA). These genomic strategies have the potential to transform our view of cancer biology and pathogenesis. This review surveys the studies performed using genome-wide analyses of melanoma, primarily in patient specimens but also in selected experimental models of melanoma. The insights gained and the challenges and potential of these approaches are discussed with respect to their ability to dissect out the molecular events that are responsible for melanoma progression.
近期可用的先进分子技术能够对全基因组范围内的基因拷贝数（DNA）变化或基因表达（RNA）进行分析。这些基因组策略有可能改变我们对癌症生物学和发病机制的看法。本综述概述了主要在患者标本以及部分黑色素瘤实验模型中，使用全基因组分析对黑色素瘤开展的研究。针对这些方法剖析黑色素瘤进展相关分子事件的能力，讨论了所获得的见解以及面临的挑战和潜力。
