Berger Michael F, Garraway Levi A
The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.
Hematol Oncol Clin North Am. 2009 Jun;23(3):397-414, vii. doi: 10.1016/j.hoc.2009.03.005.
The identification of recurrent alterations in the melanoma genome has provided key insights into the biology of melanoma genesis and progression. These discoveries have come about as a result of the systematic deployment and integration of diverse genomic technologies, including DNA sequencing, chromosomal copy number analysis, and gene expression profiling. Here, the discoveries of several key melanoma oncogenes affecting critical cell pathways are described and the role played by evolving genomics technologies in melanoma oncogene discovery is examined. These advances are being exploited to improve prognosis and treatment of melanoma patients through the development of genome-based diagnostic and targeted therapeutic avenues.
黑色素瘤基因组中复发性改变的鉴定为黑色素瘤发生和进展的生物学机制提供了关键见解。这些发现是通过系统部署和整合多种基因组技术实现的，包括DNA测序、染色体拷贝数分析和基因表达谱分析。本文描述了影响关键细胞通路的几个关键黑色素瘤癌基因的发现，并探讨了不断发展的基因组技术在黑色素瘤癌基因发现中所起的作用。这些进展正被用于通过开发基于基因组的诊断和靶向治疗途径来改善黑色素瘤患者的预后和治疗。
