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DNA序列的高度紧凑二维图形表示。

Highly compact 2D graphical representation of DNA sequences.

作者信息

Randić M, Zupan J

机构信息

National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.

出版信息

SAR QSAR Environ Res. 2004 Jun;15(3):191-205. doi: 10.1080/10629360410001697753.

Abstract

Most 2D graphical representations of primary DNA sequences, while offering visual geometrical patterns for depicting sequences, do require considerable space if enough details of such representations are to be visible. In this contribution, we consider a highly compact graphical representation of DNA, which allows visual inspection and numerical characterization of DNA sequences having a large number of nucleic acid bases. The approach is illustrated on the DNA sequences of the first exon of human beta-globin. The same graphical approach not only allows one to depict differences in composition within a single DNA, but makes possible graphical representation of protein sequences, which have hitherto evaded similar 2D visual representations.

摘要

大多数初级DNA序列的二维图形表示法,虽然能提供用于描绘序列的视觉几何图案,但如果要使此类表示的足够细节可见,确实需要相当大的空间。在本论文中,我们考虑一种高度紧凑的DNA图形表示法,它允许对具有大量核酸碱基的DNA序列进行视觉检查和数值表征。该方法在人类β-珠蛋白首个外显子的DNA序列上得到了说明。同样的图形方法不仅能让人描绘单个DNA内的组成差异,还能实现蛋白质序列的图形表示,而蛋白质序列迄今为止一直没有类似的二维视觉表示法。

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